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Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

โœ Scribed by F. Bohnenstengel; U. Hofmann; M. Eichelbaum; H. K. Kroemer

Publisher
Springer
Year
1996
Tongue
English
Weight
81 KB
Volume
51
Category
Article
ISSN
0031-6970

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Characterization of human cytochrome P45
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In vitro studies were carried out to identify the major contribution of CYP2C8, CYP2D6 and CYP3A4 to the metabolism of perospirone (cis-N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarboximide monohydrochloride dehydrate), a novel antipsychotic agent, using human liver mic