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Characterization of the Cellular Activity of PDE 4 Inhibitors Using Two Novel PDE 4 Reporter Cell Lines

✍ Scribed by Wunder, Frank; Quednau, Ramona; Geerts, Andreas; Barg, Martina; Tersteegen, Adrian

Book ID: 121333794
Publisher: American Chemical Society
Year: 2013
Tongue: English
Weight: 603 KB
Volume: 10
Category: Article
ISSN: 1543-8384
DOI: 10.1021/mp400206m

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## Abstract A simple, high‐yielding synthesis of dibutyl[^14^C]formamide ([^14^C]DBF; **1**) from ^14^CO~2~ was developed (__Scheme 1__): reaction of LiBEt~3~H and ^14^CO~2~ followed by aqueous workup gave H^14^CO~2~H in high yield. Conversion of the [^14^C]formic acid to **1** was effected by a st