✦ LIBER ✦

Characterization of the acquired immune deficiency syndrome at the cellular and molecular level

✍ Scribed by Douglas J. Barrett

Publisher: Springer
Year: 1984
Tongue: English
Weight: 737 KB
Volume: 63
Category: Article
ISSN: 0300-8177
DOI: 10.1007/bf00230156

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✦ Synopsis

The acquired immunodeficiency syndrome (AIDS) is a new disease characterized by severe dysfunction of both the T cell and B cell systems, occurring in previously healthy individuals. Affected individuals may have recurrent and chronic opportunistic infections and/or Kaposi's sarcoma or other malignancy. Analysis of the cellular and subcellular components of immunity demonstrates a profound depression in the number and function of helper/inducer T cells bearing the OKT4 (Leu 3) differentiation antigen and a concomitant defect in the synthesis of the immuno-enhancing soluble growth factor, interleukin 2 (IL-2). Hypotheses to explain the etiology of the immunological dysfunction and implications for future therapy of AIDS are discussed.

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