Characterization of T Lymphocyte Subset Alterations by Flow Cytometry in HIV Disease
โ Scribed by JANIS V. GIORGI
- Book ID
- 119869276
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 620 KB
- Volume
- 677
- Category
- Article
- ISSN
- 0890-6564
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## Abstract Flow cytometry is a key technology in the study of HIV disease. In this article, we review various cellular markers that can be measured in the setting of pathogenesis or vaccination studies, including markers of activation, differentiation, senescence, immune suppression, and function.
Current regulatory agencies specify the use of 2,500 gated lymphocytes for accurate lymphocyte immunophenotyping by flow cytometry. However, acquisition of 2,500 gated lymphocytes is often technically infeasible when testing whole blood from lymphopenic patients. Our laboratory thus compared CD3, CD