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Characterization of Raloxifene Glucuronidation in Vitro: Contribution of Intestinal Metabolism to Presystemic Clearance

✍ Scribed by Kemp, D. C.


Book ID
121647358
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2002
Tongue
English
Weight
257 KB
Volume
30
Category
Article
ISSN
0090-9556

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Although hepatic availability has been extensively studied to assess the oral bioavailability of drugs, intestinal availability has not, especially that related to conjugative metabolism (phase II metabolism). The present study assessed intestinal presystemic availability by integrating the reported