Characterization of polymeric biomaterials

✍ Scribed by Maria Cristina Tanzi, Silvia Farè

• Publisher: Woodhead Publishing
• Year: 2017
• Tongue: English
• Leaves: 502
• Series: Woodhead Publishing series in biomaterials
• Edition: First edition
• Category: Library

✦ Synopsis

Characterization of Polymeric Biomaterials presents a comprehensive introduction on the topic before discussing the morphology and surface characterization of biomedical polymers. The structural, mechanical, and biological characterization is described in detail, followed by invaluable case studies of polymer biomaterial implants.

With comprehensive coverage of both theoretical and experimental information, this title will provide scientists with an essential guide on the topic of these materials which are regularly used for clinical applications, such as implants and drug delivery devices. However, a range of novel polymers and the development and modification of existing medical polymers means that there is an ongoing need to satisfy particular design requirements. This book explains the critical and fundamentals methods to characterize polymer materials for biomedical applications.

• Presents a self-contained reference on the characterization of polymeric biomaterials
• Provides comprehensive information on how to characterize biomedical polymers in order to improve design and synthesis
• Includes useful case studies that demonstrate the characterization of biomaterial implants

✦ Table of Contents

Content: Front Cover
Characterization of Polymeric Biomaterials
Copyright
Contents
List of contributors
Part One: Characterization of morphology of polymeric biomaterials
Chapter 1: Characterization of 2D polymeric biomaterial structures or surfaces
1.1. Introduction
1.2. Optical microscopy
1.3. Stereo microscopy
1.4. Fluorescence microscopy
1.5. Electron microscopy
1.5.1. Transmission electron microscopy
1.5.2. Scanning electron microscopy
1.5.3. Environmental SEM
1.6. Scanning probe microscopy (SPM)
1.6.1. Atomic force microscopy (AFM)
References
Further reading Chapter 2: Characterization of morphology-3D and porous structure2.1. 3D porous structures: porosity and other relevant morphological parameters
2.2. Morphological characterization by microscopy observation
2.3. Determination of porosity by density measurements
2.4. Gas pycnometry
2.5. Mercury porosimetry
2.6. Flow porosimetry
2.7. Micro-CT
2.7.1. Basic principles of micro-CT
2.7.2. Micro-CT for scaffold characterization: state of the art
2.7.2.1. Scaffold characterization
2.7.2.2. In vitro cell-material interaction
2.7.2.3. Scaffold neovascularization 2.7.3. Nano-CT for scaffold characterization: state of the art2.7.4. Comparison of micro-CT with other techniques
2.8. Conclusions
References
Part Two: Surface characterization
Chapter 3: Wettability and contact angle of polymeric biomaterials
3.1. Introduction
3.1.1. General definition of wettability and contact angle
3.1.2. Importance of wettability for biomedical applications
3.2. Interpretation of biomaterial wetting properties
3.2.1. Surface energy and surface tension
3.2.2. Interfacial tension
3.2.3. Contact angle and young equation
3.3. Methods of measuring contact angle 3.3.1. Telescope goniometry3.3.2. Wilhelmy balance method
3.3.3. Drop shape analysis method
3.4. Wettability of polymeric materials and its modification for biomedical applications
3.4.1. Irradiation method
3.4.2. Plasma treatment
3.4.3. Chemical functionalization
3.4.4. Surface modification with biomolecules
3.5. Conclusions
Acknowledgments
References
Chapter 4: X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF SIMS)
4.1. Introduction
4.2. Basic principle of X-ray photoelectron spectroscopy
4.2.1. General advantages and disadvantages 4.2.2. XPS in polymeric surfaces4.2.3. XPS analysis-Example
4.3. Basic principle of time-of-flight secondary ion mass spectroscopy
4.3.1. General advantages and disadvantages
4.3.2. ToF SIMS in polymeric surfaces
4.3.3. ToF SIMS analysis-Example
4.4. Sample preparation
4.5. Examples
4.5.1. XPS characterization
4.5.2. ToF SIMS characterization
4.6. Conclusion
References
Part Three: Structure analysis
Chapter 5: Molecular weight of polymers used in biomedical applications
2.1. Introduction
2.1.1. General definition: Average molecular weight

✦ Subjects

Polymers in medicine.;Polymerization.;Polymers.;MEDICAL / Allied Health Services / Medical Technology;MEDICAL / Biotechnology