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Characterization of PO1, a new peptide ligand of the apamin-sensitive Ca2+ activated K+ channel

✍ Scribed by ZERROUK, H. ;LARABA-DJEBARI, F. ;FREMONT, V. ;MEKI, A. ;DARBON, H. ;MANSUELLE, P. ;OUGHIDENI, R. ;RIETSCHOTEN, J. VAN ;ROCHAT, H. ;MARTIN-EAUCLAIRE, M.F.


Book ID
115099908
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
648 KB
Volume
48
Category
Article
ISSN
0367-8377

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Based on the structure-activity analysis of two series of blockers of the small conductance Ca 2+activated K + (SKca) channel, a novel class of bis-quinolinium cyclophane blockers has been designed and synthesised. These compounds exhibit submicromolar activity; UCL 1530 ( 4) is a useful agent since