✦ LIBER ✦

Characterization of olanzapine (LY170053) in human liver slices by liquid chromatography/tandem mass spectrometry

✍ Scribed by Murphy, A. T.; Lake, B. G.; Bernstein, J. R.; Franklin, R. B.; Gillespie, T. A.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 166 KB
Volume: 33
Category: Article
ISSN: 1076-5174
DOI: 10.1002/(sici)1096-9888(199812)33:12<1237::aid-jms742>3.0.co;2-f

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✦ Synopsis

Olanzapine metabolism was investigated using incubation of olanzapine with human liver slices. The intent of the investigation was to identify olanzapine metabolites and determine if the human liver slice incubations could potentially produce quantities of the olanzapine glucuronides for future studies. Along with known Phase 1 olanzapine metabolites, N-desmethyl-, 2-hydroxymethyl-, and 4º-N-oxide-, a new hydroxylated species was detected. Detection of Phase 2 metabolites included known N-10-glucuronides, a quaternary glucuronide and a novel glucuronide conjugate. This investigation showed the feasibility of using human liver slices to produce sufficient quantities of olanzapine glucuronides for further studies.

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