Transport of acyclovir ester prodrugs th
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Rahul V. Tak; Dhananjay Pal; Hongwu Gao; Surajit Dey; Ashim K. Mitra
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Article
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2001
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John Wiley and Sons
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English
⚖ 208 KB
The purpose of this study is to assess the permeability of acyclovir (ACV) prodrugs through the rabbit corneal cell line (SIRC) as well as the cornea, and characterize the SIRC cell line for transport and metabolism studies of ester prodrugs. Prodrug derivatization of an acycloguanosine antiviral ag