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Characterization of Monoclonal Antibodies Recognizing Different Fragments of Cartilage Oligomeric Matrix Protein in Human Body Fluids

✍ Scribed by Vladimir Vilim; Mary Ellen Lenz; Richard Vytasek; Koichi Masuda; Karel Pavelka; Klaus E. Kuettner; Eugene J-M.A. Thonar

Book ID
115566989
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
457 KB
Volume
341
Category
Article
ISSN
0003-9861

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✍ Vishwas Ganu; Ronald Goldberg; Jane Peppard; John Rediske; Richard Melton; Shou- 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 918 KB

Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti