Characterization of interaction between doxycycline and human serum albumin by capillary electrophoresis-frontal analysis
β Scribed by Hanwen Sun; Pan He
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 132 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0173-0835
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An error introduced in the page setting stage after final proofs were checked resulted in a changeover of the images in panels A and B of Fig. 4. The correct version of Fig. 4A and B is as follows:
The interaction between drugs and human serum albumin (HSA) was investigated by capillary electrophoresis (CE). It involves stereoselectivity, drug displacement and synergism effects. Under protein-drug binding equilibrium, the unbound concentrations of drug enantiomers were measured by frontal anal
Capillary zone electrophoresis was used to monitor the interaction between bilirubin and human serum albumin. Cord blood serum samples were injected directly into an uncoated fused-silica capillary (30 cm Γ 50 mm i.d.) and separation was accomplished within 4 min without extensive sample pretreatmen
Capillary electrophoresis frontal analysis was applied to 12 low molecular weight compounds including 8 drug substances displaying a range of different properties with respect to binding affinity, binding location, structure, lipophilicity, charge at physiological pH, and electrophoretic mobility. I