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Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine

✍ Scribed by Christophe Arbus; Amine Benyamina; Pierre-Michel Llorca; Franck Baylé; Norbert Bromet; Frédéric Massiere; Ricardo P. Garay; Ahcène Hameg


Book ID
113591897
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
901 KB
Volume
32
Category
Article
ISSN
0928-0987

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In vitro studies were carried out to identify the major contribution of CYP2C8, CYP2D6 and CYP3A4 to the metabolism of perospirone (cis-N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarboximide monohydrochloride dehydrate), a novel antipsychotic agent, using human liver mic