Basic fibroblast growth factor (bFGF) is found in a variety of cells and tissues. We have previously shown that bFGF is a transforming growth factor, but only when fused to a signal peptide (sp-bFGF). Cells expressing the native bFGF are tumorigenic in nude mice only, where the tumors form at a low
Characterization of High-Molecular-Mass Forms of Basic Fibroblast Growth Factor Produced by Hepatocellular Carcinoma Cells: Possible Involvement of Basic Fibroblast Growth Factor in Hepatocarcinogenesis
โ Scribed by Shimoyama, Yutaka ;Gotoh, Masahiro ;Ino, Yoshinori ;Sakamoto, Michiie ;Kato, Koichi ;Setsuo, Setsuo
- Book ID
- 108579233
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1991
- Tongue
- English
- Weight
- 710 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0910-5050
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Endooligopeptidase A is a putative neuropeptide-metabolizing enzyme. It converts small enkephalincontaining peptides into the corresponding enkephalins and inactivates biopeptides such as bradykinin and neurotensin in vitro. We investigated the presence of endooligopeptidase A in PC12 cells. This ce
Scatchard analysis of binding of 125I-basic fibroblast growth factor (FGF) to baby hamster kidney (BHK) cells revealed the presence of two binding sites: a high affinity site with KD of 20 pM and 80,000 sites per cell and a low affinity site with KD of about 2 nM and 600,000 sites per cell. The bind