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Characterization of hemoglobin adduct formation in mice and rats after administration of [14C]butadiene or [14C]isoprene

✍ Scribed by James D. Sun; Alan R. Dahl; James A. Bond; Linda S. Birnbaum; Rogene F. Henderson

Book ID
113207272
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
800 KB
Volume
100
Category
Article
ISSN
0041-008X

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✍ Joel F. Heeg; Gordon S. Born; Wayne V. Kessler; Stanley M. Shaw; Winthrop E. Lan πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 526 KB

Meglumine labeled with carbon-14 was administered orally as 14C-meglumine salicylate to rats and dogs to study its distribution and excretion. The compound was incompletely absorbed; that which was absorbed was rapidly excreted in the urine. Peak blood levels were about 5-10 mug/ml in rats and 2-8 m