Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta
β Scribed by Awad Atalla; Edmund Maser
- Book ID
- 114008689
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 226 KB
- Volume
- 130-132
- Category
- Article
- ISSN
- 0009-2797
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The induction of micronuclei was studied in human diploid fibroblasts incubated in the presence of the tobacco-specific nitrosamine NNK. We used four fibroblast strains having a high capacity of O6-alkylguanine D N A alkyltransferase (13.0-23.3 pmol O6-methylguanine repaired per 8 Γ 10 6 cells) and
## Abstract Urinary metabolites of the tobaccoβspecific nitrosamine 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanone (NNK), 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di