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Characterization of enzymatic deficiencies of branched chain amino-acid catabolism in human fibroblasts by genetic complementation

✍ Scribed by F.X. Coudé; G. Grimber; Ph. Parvy; D. Pham Dinh; J. Bardet; J.M. Saudubray

Book ID
115757069
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
485 KB
Volume
114
Category
Article
ISSN
0006-291X

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We investigated changes in cell growth and branched chain ketoacid dehydrogenase (BCKD) activity by varying the concentrations of branched-chain amino acids (BCAAs) in culture medium of diploid fibroblasts from humans with normal BCKD and with impaired enzyme function. For logarithmic growth the two