𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Characterization of cytochrome P450-dependent dimethylhydrazine metabolism in human colon microsomes

✍ Scribed by Daniel Stralka; Henry W. Strobel


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
650 KB
Volume
68
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Metabolism of thalidomide in human micro
✍ Steve K. Teo; P. J. Sabourin; K. O'Brien; K. A. Kook; S. D. Thomas πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 117 KB πŸ‘ 1 views

Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system (CYP). In this study, we examined the extent of thalidomide metabolism by preparations of pooled human microsomes, microsomes containing cloned human CYP isozymes (CYP1A2,

Inhibition of fipronil and nonane metabo
✍ Hyun Joo; Kyoungju Choi; Randy L. Rose; Ernest Hodgson πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 200 KB

## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th

Cytochrome P450-dependent toxicity of da
✍ Shobana Ganesan; Rajnish Sahu; Larry A Walker; Babu L. Tekwani πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 246 KB πŸ‘ 1 views

## Abstract The most prominent adverse effects seen during treatment with dapsone, an antibacterial and antiprotozoal agent, are hemolysis and methemoglobinemia. An __in vitro__ microsomal/cytochrome P~450~ (CYP)‐linked assay, which allows reactive metabolites generated __in situ__ to react with th

Characterization of human cytochrome P45
✍ Atsushi Kitamura; Yoshiko Mizuno; Kiyoshi Natsui; Masashi Yabuki; Setsuko Komuro πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 350 KB πŸ‘ 1 views

In vitro studies were carried out to identify the major contribution of CYP2C8, CYP2D6 and CYP3A4 to the metabolism of perospirone (cis-N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarboximide monohydrochloride dehydrate), a novel antipsychotic agent, using human liver mic

In vitro metabolism of mirtazapine enant
✍ Seetal Dodd; David W. Boulton; Graham D. Burrows; C. Lindsay De Vane; Trevor R. πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 52 KB πŸ‘ 1 views

The metabolism of mirtazapine enantiomers was investigated in vitro using human lymphoblast microsomes transfected with human cDNA to overexpress either CYP1A2, CYP2C9, CYP2C19, CYP2D6 or CYP3A4 and assayed for mirtazapine enantiomers using a validated chiral method of high-performance liquid chroma