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Characterization of BIS20x3, a bi-specific antibody activating and retargeting T-cells to CD20-positive B-cells

✍ Scribed by Withoff, S; Bijman, M N A; Stel, A J; Delahaye, L; Calogero, A; Jonge, M W A de; Kroesen, B J; Leij, L de


Book ID
111724483
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
88 KB
Volume
84
Category
Article
ISSN
0007-0920

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Bi20 (fBTA05), a novel trifunctional bis
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## Abstract Trifunctional bispecific antibodies can efficiently mediate tumor cell killing by redirecting T cells and immune accessory cells to the tumor cell. Here, we describe the new trifunctional antibody, Bi20 (FBTA05, anti‐CD20 Γ— anti‐CD3), that connects B cells and T cells __via__ its variab