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Immunotherapy of recurrent B-cell malignancies after allo-SCT with Bi20 (FBTA05), a trifunctional anti-CD3 × anti-CD20 antibody and donor lymphocyte infusion

✍ Scribed by Buhmann, R; Simoes, B; Stanglmaier, M; Yang, T; Faltin, M; Bund, D; Lindhofer, H; Kolb, H-J

Book ID
109840482
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
278 KB
Volume
43
Category
Article
ISSN
0007-1188

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Bi20 (fBTA05), a novel trifunctional bis
Bi20 (fBTA05), a novel trifunctional bispecific antibody (anti-CD20 × anti-CD3), mediates efficient killing of B-cell lymphoma cells even with very low CD20 expression levels
✍ Michael Stanglmaier; Margot Faltin; Peter Ruf; Annette Bodenhausen; Petra Schröd 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 312 KB

## Abstract Trifunctional bispecific antibodies can efficiently mediate tumor cell killing by redirecting T cells and immune accessory cells to the tumor cell. Here, we describe the new trifunctional antibody, Bi20 (FBTA05, anti‐CD20 × anti‐CD3), that connects B cells and T cells __via__ its variab