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Characterization of adapter protein NRBP as a negative regulator of T cell activation

✍ Scribed by Hui Wang; Zhi-xin Lin; Jun Wu

Book ID
107622593
Publisher
Chinese Electronic Periodical Services
Year
2008
Tongue
English
Weight
264 KB
Volume
13
Category
Article
ISSN
1007-1172

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Negative regulation of T cell activation
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T cell activation is negatively regulated by cytotoxic T lymphocyte antigen 4 (CTLA-4) and the killer cell inhibitory receptors. Endocytosis and signaling of CTLA-4 are regulated by tyrosine phosphorylation. While T cell activation is mediated by phosphorylation of immunoreceptor tyrosine-based acti