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Characterization of a new mouse p53 variant: loss-of-function and gain-of-function

✍ Scribed by Chan, James Yi-Hsin; Chen, Ying-Chuan; Liu, Shu-Ting; Chou, Wei-Yuan; Ho, Ching-Liang; Huang, Shih-Ming

Book ID
125396990
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
842 KB
Volume
21
Category
Article
ISSN
1021-7770

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## Abstract Cancer might result from both the aberrant activation of genes, whose physiological tuning is essential for the life of a normal cell, and the inactivation of tumor suppressor genes, whose main job is to preserve the integrity of cell genome. Among the latter, p53 is considered a key tu