Characterization of a new human papillomavirus (HPV 41) from disseminated warts and detection of its DNA in some skin carcinomas

✍ Scribed by M. Grimmel; E.-M. De Villiers; Ch. Neumann; M. Pawlita; H. zur Hausen

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: French
• Weight: 476 KB
• Volume: 41
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910410103

✦ Synopsis

A new human papillomavirus type (HPV 41). distantly related to known HPV prototypes, was isolated from a patient with disseminated facial, peri-anal and foot warts (epidermodysplasia verruciformis was not diagnosed). The viral DNA was molecularly cloned in 2 BarnHl restriction fragments with sizes of 6.5 kb and 0.98 kb, respectively. The classification 01 this cloned DNA as a new type is based on the degree of crosshybridization with 40 HPV types under conditions of varying stringency. A total of 106 benign and malignant skin lesions, as well as 71 malignant tumours of different origins, were screened for the presence of HPV-related sequences. In 2 out of 10 squamous-cell carcinomas and in I of 3 arsenic keratoses HPV 41 DNA sequences could be detected.