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Characterization of a humanized anti-CD20 antibody with potent antitumor activity against B-cell lymphoma

✍ Scribed by Lan Wu; Chong Wang; Dapeng Zhang; Xunming Zhang; Weizhu Qian; Lei Zhao; Hao Wang; Bohua Li; Yajun Guo

Book ID
116335404
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
781 KB
Volume
292
Category
Article
ISSN
0304-3835

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## Abstract CD19 is an attractive therapeutic target for treating human B‐cell tumors. In our study, chimeric (c) divalent (cHD37) and tetravalent (cHD37‐DcVV) anti‐CD19 monoclonal antibodies (MAbs) were constructed, expressed and evaluated for their binding to human 19‐positive (CD19^+^) tumor cel