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A complement-dependent cytotoxicity-enhancing anti-CD20 antibody mediating potent antitumor activity in the humanized NOD/Shi-scid, IL-2Rγnullmouse lymphoma model

✍ Scribed by Fumihiko Sato; Asahi Ito; Takashi Ishida; Fumiko Mori; Hisashi Takino; Atsushi Inagaki; Masaki Ri; Shigeru Kusumoto; Hirokazu Komatsu; Shinsuke Iida; Noriko Okada; Hiroshi Inagaki; Ryuzo Ueda

Book ID: 105967809
Publisher: Springer-Verlag
Year: 2010
Tongue: English
Weight: 744 KB
Volume: 59
Category: Article
ISSN: 0340-7004
DOI: 10.1007/s00262-010-0905-2

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✍ Asahi Ito; Takashi Ishida; Hiroki Yano; Atsushi Inagaki; Susumu Suzuki; Fumihiko 📂 Article 📅 2008 🏛 Springer-Verlag 🌐 English ⚖ 966 KB

## Purpose There are no suitable small animal models to evaluate human antibody-dependent cellular cytotoxicity (ADCC) in vivo, due to species incompatibilities. Thus, the first aim of this study was to establish a human tumor-bearing mouse model in which human immune cells can engraft and mediate