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Characterization of (5Z)-7-[3-endo-[(4-iodophenylsulfonyl) amino]-bicyclo[2.2.1]hep-2-exo-yl]heptenoic acid (IS-145) as an antagonist for the study of thromboxane A2 receptor

โœ Scribed by Kan, W.M.; Tai, H.H.


Book ID
122767688
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
681 KB
Volume
48
Category
Article
ISSN
0952-3278

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Improved synthesis of (5Z)-7-(3-endo-{(b
โœ Wai Ming Kan; Hsin-Hsiung Tai ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 567 KB

An improved synthetic scheme for (5Z)-7-[3-endo-[(benzenesulfonamido)-bicyclo[2.2.1]heptyl I-hept-5-enoic acid (S145) and its analogs has been designed. The procedure involves direct sulfonylation of 2-allyl-3-aminobicyclo[2.2. l]heptane intermediate followed by ozonolysis and addition of a C5 carbo