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Characterization of (2R, 3S)-2-({[4-(2-butynyloxy)phenyl]sulfonyl}amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-α converting enzyme

✍ Scribed by Yuhua Zhang; Martin Hegen; Jun Xu; James C. Keith Jr.; Guixian Jin; Xuemei Du; Terri Cummons; Barbara J. Sheppard; LinHong Sun; Yi Zhu; Vikram R. Rao; Qin Wang; Weixin Xu; Rebecca Cowling; Cheryl L. Nickerson-Nutter; Jay Gibbons; Jerry Skotnicki; Lih-Ling Lin; Jeremy Levin


Book ID
118460679
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
404 KB
Volume
4
Category
Article
ISSN
1567-5769

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✍ Aihua Wang; Yan Zhang; Songfeng Lu; William V. Murray; Gee-Hong Kuo 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 140 KB

## Abstract magnified image An efficient and scalable synthesis of the potent CETP inhibitor, (2__R__,α__S__)‐3,4‐dihydro‐2‐[3‐(1,1,2,2‐tetrafluoroethoxy)phenyl]‐5‐[3‐(trifluoromethoxy)phenyl]‐α‐(trifluoromethyl)‐1(2__H__)‐quinolineethanol 1, is described. One of the important intermediates, tetrah