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Characterization of 18 new BoLA-DRB3 alleles

✍ Scribed by J-C. Maillard; C. Renard; P. Chardon; 1I. Chantal; A. Bensaid


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
227 KB
Volume
30
Category
Article
ISSN
0268-9146

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## Summary Bovine MHC (__BoLA__‐) __DRB3__ alleles encoded by the __DH8A__, __DH22A__ and __DH24A__ class II haplotypes were cloned from cDNA and characterized by sequence analysis. Comparison with other full‐length __DRB3__ sequences suggested that __DRB3__ alleles may have evolved through multipl

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Potential associations were investigated between bovine leucocyte antigen (BoLA) alleles and occurrence of disease. Cows (Holstein n = 835; Jersey n = 66) were examined for polymorphisms of the second exon of the BoLA-DRB3 gene, using the polymerase chain reaction (PCR), followed by digestion of the