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Characterization by Hg2+ of two different pathways for mitochondrial Ca2+ release

✍ Scribed by Edmundo Chávez; Cecilia Zazueta; Enrique Díaz; JoséA. Holquín

Book ID
115728970
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
361 KB
Volume
986
Category
Article
ISSN
0005-2736

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Characterization of two different Ca2+up
Characterization of two different Ca2+uptake and IP3-sensitive Ca2+release mechanisms in microsomal Ca2+pools of rat pancreatic acinar cells
✍ T. Ozawa; F. Thévenod; I. Schulz 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 857 KB

We have examined the effect of the Ca2+ (Mg2+)-ATPase inhibitors thapsigargin (TG) and vanadate on ATP-dependent 45Ca2+ uptake into IP3-sensitive Ca2+ pools in isolated microsomes from rat pancreatic acinar cells. The inhibitory effect of TG was biphasic. About 40-50% of total Ca2+ uptake was inhibi