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Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation

✍ Scribed by Laura Vay; Esther Hernández-SanMiguel; Jaime Santo-Domingo; Carmen D. Lobatón; Alfredo Moreno; Mayte Montero; Javier Alvarez

Book ID
110115380
Publisher
Cambridge University Press
Year
2007
Tongue
English
Weight
785 KB
Volume
580
Category
Article
ISSN
0022-3751

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In rat pituitary gonadotropes, gonadotropin-releasing hormone (GnRH) stimulates rhythmic release of Ca2+ from stores sensitive to inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], which in turn induces an oscillatory activation of apamin-sensitive Ca2+-activated K+ current, IK(Ca). Since GnRH also activa