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Characteristics of murine C-type viruses. III. Antigenic conversion and focus induction

✍ Scribed by Gertrud Grundner; Eva Maria Fenyö; Eva Klein

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
465 KB
Volume
13
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Viruses produced by two Moloney lymphoma sublines (Y and Yr), and their hybrids with a mouse L cell subline (YL and YrL) were tested for antigenic conversion and focus induction on JLS‐V9 and D56 (S + L −) cells. Two infectivity patterns were encountered. Both indicator cell lines were converted antigenically by the Y and YT viruses, whereas only D56 cells, and not JLS‐V9 cells, were converted by the Yr and YrL viruses. When infection of D56 cells was scored by both antigenic conversion and focus induction, further variations in infectivity patterns were found. The viruses produced by the YAC‐A9 and YACIR‐A9 hybrid cells (YL and YrL) appeared to be similar to the viruses produced by each of the lymphoma parents.

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