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Characteristics of chromosome instability in the human lymphoblast cell line WTK1

โœ Scribed by Jeffrey L Schwartz; Robert Jordan; Helen H Evans

Book ID
114135110
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
302 KB
Volume
129
Category
Article
ISSN
0165-4608

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โœ S.K. Kachhap; S.P. Vetale; P. Dange; S.N. Ghosh ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 462 KB

Using clonal cell cultures, a significant increase in chromosomal aberrations (aneuplolidy, dicentrics and chromatid breaks) were observed in MCFโ€7 cells compared with HeLa. BRCA1 expression was lower in MCFโ€7 cells than in HeLa cells. Since BRCA1 is known to play a role in the maintenance of chromo