Characteristics of a highly purified pyrogenic lipopolysaccharide

✍ Scribed by Gaylord B. Castor; Nathan Kantor; Everett Knoll; Jocelyn Blakely; Jean K. Nielsen; Joseph O. Randolph; Amiel Kirshbaum

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 351 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600601035

✦ Synopsis

to those that occur in the course of hepatic injury such as carbon tetrachloride or ethionine poisoning (9-1 1). It was demonstrated that these toxicants produce fatty livers by interfering with hepatocellular lipoprotein synthesis or release (4). Furthermore, it was shown that the presence of numerous liposomes and the alterations in the Golgi apparatus, consisting of saccular dilatation and disappearance of their vacuolar content (also seen in the present experiments), are electron microscopic signs indicative of the failure of lipoprotein secretion (4, 6, 8, 12). Further investigations are, however, required to verify whether a similar mechanism is also responsible for the fatty degeneration caused by W-1372.