In order to evaluate the role of BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer, 97 patients with sporadic breast cancer were analyzed for mutations in the BRCA1 and BRCA2 coding regions, by using a combination of fluorescent-conformation sensitive gel electrophore
Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer
โ Scribed by Haeyoung Kim, Dae-Yeon Cho, Doo Ho Choi, Su-Youn Choi, Inkyung Shin, Won Park, Seung Jae Huh, Sung-Hee Han, Min Hyuk Lee, Sei Hyun Ahn, Byung Ho Son, Sung-Won Kim, Bruce G. Haffty
- Book ID
- 118796669
- Publisher
- Springer US
- Year
- 2012
- Tongue
- English
- Weight
- 219 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0167-6806
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Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
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