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Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity

โœ Scribed by Jones, D J L; Lamb, J H; Verschoyle, R D; Howells, L M; Butterworth, M; Lim, C K; Ferry, D; Farmer, P B; Gescher, A J


Book ID
109998228
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
136 KB
Volume
91
Category
Article
ISSN
0007-0920

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The four stereoisomers of the parent keto acid of the oximino drug ximoprofen have been prepared in high enantiomeric purity. The stereochemistry in the propionic acid chain was established by the combination of Sharpless epoxidation followed by stereoselective hydrogenolysis of the benzylic carbon-