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Effects of the Mango Components Mangiferin and Quercetin and the Putative Mangiferin Metabolite Norathyriol on the Transactivation of Peroxisome Proliferator-Activated Receptor Isoforms

✍ Scribed by Wilkinson, Ashley S.; Monteith, Gregory R.; Shaw, P. Nicholas; Lin, Chun-Nam; Gidley, Michael J.; Roberts-Thomson, Sarah J.

Book ID
121014445
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
317 KB
Volume
56
Category
Article
ISSN
0021-8561

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During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination. So far, it is not known whether xenobiotics can modulate the UGDH gene expression. This question was tested b