Internodes of maize (Zea mays L, Co125), harvested 5 days after anthesis, were sectioned into Ðve equal parts and samples of sclerenchyma and parenchyma cells mechanically isolated from each section. Phenolic acids and syringyl and guaiacyl degradation products of lignin were released from the walls of the two cell types by microwave digestion with 4 M NaOH. Aryl ether bonded units were selectively released by thioacidolysis. Total phenolic content of cell walls from the youngest (basal) sections were approximately two-thirds of those of the oldest, topmost sections (parenchyma 70É8È99É0 and sclerenchyma 72É5È 114É1 mg g~1) indicating that the process of ligniÐcation was already well advanced amongst most of the cell walls of the youngest section. The total phenolic content was marginally, but signiÐcantly, greater (P \ 0É05) in sclerenchyma walls than in parenchyma walls at all stages of maturity. There was no signiÐcant di †erence in phenolic acid concentrations between cell types from the same section but p-coumaric acid concentration increased with maturity (P \ 0É001) in walls from both cell types. The increase in p-coumarate with age was matched by an increased recovery of syringyl units resulting in a constant coumaroyl : syringyl molar ratio. Recovery of acetosyringone was signiÐcantly greater (P \ 0É001) from sclerenchyma than parenchyma walls and, in sclerenchyma, acetosyringone as a proportion of total syringyl recovery, increased sig-niÐcantly with age (P \ 0É015). Digestion with NaOH and thioacidolysis released comparable amounts of guaiacyl residues but NaOH digestion released approximately twice the amount of syringyl residues. This di †erence may be explained by the retention of the ester-bond between p-coumaric acid and syringyl units during thioacidolysis but not during digestion with 4 M alkali. The similarity in phenolic composition suggested that both cell types, despite their considerable anatomical di †erences, were exposed to a common Ñux of lignin precursors during the later stages of ligniÐcation as illustrated by the internode sections. Di †erences between cell walls arose because of di †erences in the regiochemistry of precursor incorporation.