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Changes of transition temperatures of phosphatidylcholine and phosphatidylglycerol in presence of amphiphilic drugs

✍ Scribed by Achim Harder; Hildegard Debuch

Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
277 KB
Volume
39
Category
Article
ISSN
0009-3084

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✦ Synopsis

The transition temperature of phosphatidylglycerol (PG) was reduced to lower temperatures in presence of propranolol, imipramine, amitriptyline and chlorpromazine. This effect was dependent on drug concentration and was smallest with propranolol. The tluidizing effect, however, increased from propranolol to chlorpromazine according to the octanol/H~O partition coefficients.

When the two phospholipids PG and phosphatidylcholine (PC) were compared, the presence of drug lead to a more pronounced reduction of the transition temperature in the case of the acidic phospholipid than in the case of the neutral one.

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