Changes of the level of cytochrome P-450 and NADPH-cytochrome P-450 reductase in rats with hereditary degeneration of the retina
β Scribed by N. D. Shushakova; M. G. Efimova
- Publisher
- Springer US
- Year
- 1994
- Tongue
- English
- Weight
- 445 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0007-4888
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NADPH-cytochrome P-450 oxidoreductase (P-450 red) transfers reducing equivalents from NADPH to cytochrome P-450 (P-450) in the monooxygenase system. Detergent solubilized proteins from the membrane fraction of neonatal rat epidermis were purified by 2',5'-ADP-agarose affinity column chromatography.
## Abstract Summary: NADPHβcytochrome P450 reductase (CPR or POR) is the obligatory electron donor for all microsomal cytochrome P450 (CYP or P450)βcatalyzed monooxygenase reactions. Disruption of the mouse __Cpr__ gene has been reported to cause prenatal developmental defects and embryonic lethali