Changes of insulin effect on lipogenesis and insulin binding receptors during hypokinesia
β Scribed by L. Macho; M. Fickova; S. Zorad
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 312 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0094-5765
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We investigated the effect of phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator on insulin receptors and insulin action in freshly isolated and primary cultures of rat hepatocytes. PMA (1 x 10(-7) M) did not alter insulin receptor numbers or affinity either acutely or chronic
Insulin has both short- and long-term effects on cellular metabolism. The short-term effects are known to involve the insulin receptor, a protein kinase capable of phosphorylating itself and other proteins. The role of the receptor was elucidated by studies of a mutant insulin receptor which lacked