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Changes of glial–neuronal interaction and metabolism after a subconvulsive dose of pentylenetetrazole

✍ Scribed by Haytham Eloqayli; Carl Bredo Dahl; K.Gunnar Götestam; Geirmund Unsgård; Ursula Sonnewald

Book ID
116764513
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
113 KB
Volume
45
Category
Article
ISSN
0197-0186

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## Abstract Alexander disease is a rare and usually fatal neurological disorder characterized by the abundant presence of protein aggregates in astrocytes. Most cases result from dominant missense __de novo__ mutations in the gene encoding glial fibrillary acidic protein (GFAP), but how these mutat