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Changes in water diffusion and relaxation properties of rat cerebrum during status epilepticus

✍ Scribed by J. Zhong; O. A. C. Petroff; J. W. Prichard; J. C. Gore

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
619 KB
Volume
30
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Diffusion‐weighted (DW) imaging has been used to record changes associated with status epilepticus (SE) in rat brain. It was found that the apparent diffusion coefficient (ADC) of water in brain decreased14–18% during SE, and it fell a further 20–22% when the animals were sacrificed. The transverse decay time constant T~2~ showed corresponding reductions, but no significant changes were seen in relaxation times T~1~ or T~2~ values. Changes in ADC in status epilepticus are similar to those seen in stroke and ischemia but occur under very differ ret conditions of blood flow and metabolism.

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