Changes in sensitivity of hepatocytes isolated from regenerating rat liver to the growth inhibitory action of transforming growth factor beta
β Scribed by Alastair J. Strain; David J. Hill
- Book ID
- 114796707
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 735 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0106-9543
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TGF-beta is a potent inhibitor of EGF-induced DNA synthesis in primary rat hepatocyte cultures. Norepinephrine (NE) was shown to modulate this inhibition of DNA synthesis. It produced a five-fold increase, from 2.8 pM to 14.4 pM, in the IDSo for TGF-beta. The effect was dose-dependent and was signif
To clarify the role of transforming growth factor-b (TGF-b) and its receptors in hepatocyte growth, we studied the expression of TGF-b1 and its receptors and the sensitivity to growth inhibition by TGF-b1 protein in rat hepatocytes derived from resting and regenerating livers. In hepatocytes derived