𝔖 Bobbio Scriptorium
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Changes in plasma and erythrocyte chlorpromazine concentrations during sample storage

✍ Scribed by Robert C. Young; Richard W. Nysewander

Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
253 KB
Volume
4
Category
Article
ISSN
0731-7085

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✦ Synopsis

Plasma CPZ concentrations were determined in physically healthy inpatients receiving therapeutic doses of chlorpromazine hydrochloride. Heparinized venous blood samples were obtained in evacuated tubes (Venoject; Kimble-Terumo).

Refrigeration of whole blood

To test the effect of refrigerated storage of whole blood on plasma and erythrocyte CPZ determinations, heparinized blood from nine patients was stored upright in collection tubes in the dark at 4Β°C for 24 or 168 h prior to centrifugation. After centrifugation at 850 g for 15 min, aliquots of plasma and packed cells were immediately frozen at -70Β°C prior to extraction and analysis.

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