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Changes in Liver Histology during Methotrexate Therapy of Psoriasis Correlated to the Concentration of Methotrexate and Folate in Erythrocytes

✍ Scribed by Hendel, J. ;Poulsen, H. ;Nyfors, B. ;Nyfors, A.


Book ID
114800533
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
402 KB
Volume
56
Category
Article
ISSN
0001-6683

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Changes in the mechanisms of folate incorporation were studied in cells treated with low concentrations of methotrexate in order to evaluate their contribution to the development of resistance to antifolate drugs. The uptake of methotrexate via reduced-folate system, the membrane-associated high-aff