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Changes in erythrocyte ouabain binding with age in down's syndrome and in controls

✍ Scribed by Dr G. J. Naylor; B. Shepherd; D. Findlay; S. Young; D. McRae

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
270 KB
Volume
5
Category
Article
ISSN
0885-6230

No coin nor oath required. For personal study only.

✦ Synopsis

Ouabain binding was estimated in erythrocytes from 31 patients with trisomy 21 and 32 matched mentally handicapped controls. The ouabain binding of the control group decreased significantly with age, as expected, but this change did not occur in the Down's syndrome group. However, the ouabain binding of the younger (less than 40 years) Down's group was significantly lower than that of the younger controls and simply remained low in the older group.

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