Changes in diffusion through the brain extracellular space
✍ Scribed by Manuel Mota; José A. Teixeira; José B. Keating; Alexander Yelshin
- Book ID
- 111709359
- Publisher
- Portland Press
- Year
- 2004
- Tongue
- English
- Weight
- 182 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0885-4513
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Brain extracellular space (ECS) constitutes a porous medium in which diffusion is subject to hindrance, described by tortuosity, lambda = (D/D\*)1/2, where D is the free diffusion coefficient and D\* is the effective diffusion coefficient in brain. Experiments show that lambda is typically 1.6 in no
## Abstract The apparent diffusion coefficients (ADCs) of a series of markers concentrated in the extracellular space of normal rat brain were measured to evaluate, by inference, the ADC of water in the extracellular space. The markers (mannitol, phenylphosphonate, and polyethylene glycols) are def