Cirrhosis is characterized by a marked increase in the deposition of type I collagen and in the expression of the type I collagen genes d ( 1 ) and &(I). Although al(1) gene regulation has been extensively studied in cultured cells, these results may not be applicable to hepatic fibrogenesis in uiuo
✦ LIBER ✦
Changes in albumin, α-fetoprotein and collagen gene transcription in ccl4-induced hepatic fibrosis
✍ Scribed by Arturo Panduro; Fouad Shalaby; Luis Biempica; David A. Shafritz
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 1014 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0270-9139
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## Abstract In the interphase nucleus the DNA of higher eukaryotes is organized in loops anchored to a substructure known as the nuclear matrix (NM). The topological relationship between gene sequences located in the DNA loops and the NM appears to be very important for nuclear physiology because p