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Change and stabilization of the amyloid-β(1–40) secondary structure by fluorocompounds

✍ Scribed by Euridice P. Vieira; Horst Hermel; Helmuth Möhwald


Book ID
108497822
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
281 KB
Volume
1645
Category
Article
ISSN
1570-9639

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## Abstract **Summary:** The conformational change of the 39–43 residues of the amyloid __β__‐peptide (A__β__) toward a __β__‐sheet enriched state promotes self‐aggregation of the peptide molecules and constitutes the major peptide component of the amyloid plaques in Alzheimer patients. The crucial