The neural basis of the amnesia characterizing early Alzheimer's disease (AD) remains uncertain. Postmortem pathological studies have suggested early involvement of the mesial temporal lobe, whereas in vivo metabolic studies have shown hypometabolism of the posterior cingulate cortex. Using a techni
โฆ LIBER โฆ
Challenging assumptions about Alzheimer's disease: Mild cognitive impairment and the cholinergic hypothesis
โ Scribed by John C. Morris
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 35 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0364-5134
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Recent studies indicate that there is a marked reduction in trkA-containing nucleus basalis neurons in end-stage Alzheimer's disease (AD). We used unbiased stereological counting procedures to determine whether these changes extend to individuals with mild cognitive impairment (MCI) without dementia