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Challenges in the development of anti-epidermal growth factor receptor therapies in breast cancer

✍ Scribed by Carlos L Arteaga; Cristina I Truica

Book ID
114473474
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
98 KB
Volume
31
Category
Article
ISSN
0093-7754

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Recent studies demonstrated that tumors overexpressing the epidermal growth factor receptor (EGF-R, erbB-1) are associated with poor clinical outcome. This led to the development of a variety of monoclonal antibodies targeting the extracellular domain of this receptor tyrosine kinase. The aim of our